Cognition

Semax

ACTH(4-7)-Pro-Gly-Pro

Semax is a synthetic peptide built from a fragment of the hormone ACTH, developed and studied mainly in Russia. It is not FDA-approved, and most of its clinical literature has not been replicated in Western trials.

Key facts

  • Commonly discussed for: focus, memory and stroke recovery.
  • Evidence (C): Human data come mostly from Russian clinical studies, such as a 2018 study of 110 ischemic-stroke patients comparing rehabilitation with and without Semax. These are small and not large, independently replicated randomized trials.
  • FDA status: PCAC recommended. On July 24, 2026 the PCAC voted 8-5 (1 abstention) to recommend Semax for the 503A Bulks List for cerebral ischemia, migraine and trigeminal neuralgia; FDA must still publish a proposed rule; none appeared in the Federal Register as of October 1, 2026.
  • Legitimate access: No clear legal route yet.
  • Last reviewed: October 1, 2026.

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Sources