Longevity

Epitalon

Epithalon, Ala-Glu-Asp-Gly

Epitalon is a synthetic four-amino-acid peptide modeled on epithalamin, an extract from the pineal gland. It is popular in longevity circles, but it is not FDA-approved and its human evidence is thin.

Key facts

  • Commonly discussed for: healthy aging, sleep and telomere support.
  • Evidence (D): Most data are cell and animal studies (for example telomere work in human cell lines). Human reports come largely from one Russian research group, and the best known, a 266-person elderly cohort, used the epithalamin extract rather than synthetic Epitalon.
  • FDA status: PCAC recommended. On July 24, 2026 the PCAC voted 7-4 (1 abstention) to recommend Epitalon for the 503A Bulks List for insomnia; FDA must still publish a proposed rule; none appeared in the Federal Register as of October 1, 2026.
  • Legitimate access: No clear legal route yet.
  • Last reviewed: October 1, 2026.

Read the deep dives

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Sources